产品货号：
Z36130
中文名称：
PIP5K3/PIKFYVE (Phospho-Ser307)抗体
英文名称：
Anti-PIP5K3/PIKFYVE (Phospho-Ser307) Antibody (Clone#OTI1D3)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PIP5K3/PIKFYVE (Phospho-Ser307) Antibody (Clone#OTI1D3) |
| 指标别名 | CFD;FAB1;KIAA0981;PIKFYVE;PIP5K;PIP5K3;PIPkin III;Type III PIP kinase |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | PIKFYVE |
| 克隆号 | OTI1D3 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Full length human recombinant protein of human PIKFYVE (NP_001171471) produced in E.coli. |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions,membrane trafficking,and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes.Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring.This gene encodes an enzyme (PIKfyve;also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate.The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns.In contrast,PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns.In addition to being a lipid kinase,PIKfyve also has protein kinase activity.PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes.Mutations in this gene cause corneal fleck dystrophy (CFD);an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma.Histologically,these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles.Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq,May 2010] |
| Uniprot ID | Q9Y2I7 |
| 基因名全称 | 1-phosphatidylinositol 3-phosphate 5-kinase |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：PIP5K3/PIKFYVE (Phospho-Ser307)抗体，PIP5K3抗体，PIKFYVE (Phospho-Ser307)单抗