产品货号:
Z35812
中文名称:
MYD88抗体
英文名称:
Anti-MYD88 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-MYD88 Antibody |
指标别名 | MYD88;MYD88D |
克隆性 | Monoclonal |
检验物种 | human |
应用范围 | WB,IHC,ICC/IF,FCM |
基因名称 | MYD88 |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | A synthesized peptide derived from human MyD88 Members of the Toll-like receptor (TLR) family,named for the closely related Toll receptor in Drosophila,play a pivotal role in innate immune responses.TLRs recognize conserved motifs found in various pathogens and mediate defense responses.Triggering of the TLR pathway leads to the activation of NF- Kappa B and subsequent regulation of immune and inflammatory genes. |
实际分子量 | 33KD |
成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
纯化方式 | Affinity-chromatography |
浓度 | 500μg/mL |
产品形态 | 溶液 |
保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
背景资料 | MYD88(MYELOID DIFFERENTIATION PRIMARY RESPONSE GENE 88),is a protein that,in humans,is encoded by the MYD88 gene.MyD88 is a key downstream adapter for most Toll-like receptors(TLRs) and interleukin-1 receptors(IL1Rs).And it is mapped on 3p22.2.MYD88 encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response.This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways.Qverexpression of MYD88 caused an increase in the level of transcription from the interleukin-8 promoter.The C-terminal domain of MYD88 has significant sequence similarity to the cytoplasmic domain of IL1RAP.Inhibiting the IL1R-MYD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death,and do so in a way that might not compromise tissue repair or host defense against pathogens. |
Uniprot ID | Q99836 |
推荐稀释比 | Western blot (WB) 1:500~2000 Immunohistochemistry in paraffin section (IHC) 1:20~100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20~100 Flow cytometry (FCM) 1:20 |
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