产品货号：
Z35759
中文名称：
NLK抗体
英文名称：
Anti-NLK Antibody (Clone#1146CT24.2.1)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NLK Antibody (Clone#1146CT24.2.1) |
| 指标别名 | LAK1;Nemo like kinase;Nlk |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | NLK |
| 克隆号 | 1146CT24.2.1 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2a |
| 免疫原 | Purified His-tagged NLK protein was used to produced this monoclonal antibody. |
| 计算分子量 | 58kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination.Positive effector of the non-canonical Wnt signaling pathway,acting downstream of WNT5A,MAP3K7/TAK1 and HIPK2.Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1.The NLK-SETDB1 complex subsequently interacts with PPARG,leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing.The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs).Negative regulator of the canonical Wnt/beta-catenin signaling pathway.Binds to and phosphorylates TCF7L2/TCF4 and LEF1,promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA,as well as the ubiquitination and subsequent proteolysis of LEF1.Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes.Negative regulator of the Notch signaling pathway.Binds to and phosphorylates NOTCH1,thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1,RBPJ/RBPSUH and MAML1.Negative regulator of the MYB family of transcription factors.Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP.Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself.Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3,which is in turn required for activation of NLK by MAP3K7/TAK1. |
| Uniprot ID | Q9UBE8 |
相关搜索：NLK抗体，NLK单抗，Anti-NLK Antibody (Clone#1146CT24.2.1)