产品货号：
Z35595
中文名称：
NCOA1抗体
英文名称：
Anti-NCOA1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NCOA1 Antibody |
| 指标别名 | nuclear receptor coactivator 1;F-SRC-1;KAT13A;RIP160;SRC1;bHLHe42;bHLHe74;NCOA1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | NCOA1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human KAT13A/SRC1 Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion.Involved in the coactivation of different nuclear receptors,such as for steroids (PGR,GR and ER),retinoids (RXRs),thyroid hormone (TRs) and prostanoids (PPARs). |
| 实际分子量 | 157KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The nuclear receptor coactivator 1 (NCOA1),also known as SRC1,is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity.NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors.NCOA1,in turn,acylates histones,which makes downsteam DNA more accessible to transcription.Hence,NCOA1 assists nuclear receptors in the upregulation of DNA expression.It has been found that NCOA1 can enhance the transcriptional activity of ligand-bound PGR but does not alter the basal activity of the target promoter.It also enhances estrogen receptor,glucocorticoid receptor,thyroid hormone receptor,and retinoid X receptor transcriptional activities through their cognate DNA response elements in the presence of hormone.What’s more,SRC1 may play a role as a bridging molecule between nuclear hormone receptors and general transcription factors. |
| Uniprot ID | Q15788 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：NCOA1抗体，NCOA1单抗，Anti-NCOA1 Antibody