产品货号：
Z35425
中文名称：
ORAI3抗体
英文名称：
Anti-ORAI3 Antibody (Clone#2H2G9)
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ORAI3 Antibody (Clone#2H2G9) |
| 指标别名 | ORAI3;Protein orai 3;TMEM142C;Transmembrane protein 142C |
| 克隆性 | Monoclonal |
| 检验物种 | human,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | ORAI3 |
| 克隆号 | 2H2G9 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2a |
| 免疫原 | A 19 amino acid synthetic peptide from near the carboxy terminus of human ORAI3. |
| 计算分子量 | 31kDa |
| 成分 | ORAI3 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | ORAI3 Monoclonal Antibody is immunoaffinity chromotography purified IgG. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | ORAI3 monoclonal antibody can be stored at -20℃,stable for one year. |
| 背景资料 | Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels.ORAI3 is one of two mammalian homologs to ORAI1,a recently identified four-transmembrane spanning protein that is an essential component of CRAC.All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1,the store-activated endoplasmic reticulum Ca++ sensor.However,ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1,indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.Na+ currents through ORAI1,2 and 3 channels were equally inhibited by extracellular Ca++,indicating that each have similar affinities for Ca++ within the selectivity filter.This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.Larger molecular weight bands are sometimes seen in SDS-PAGE;these may represent post-translationally modified ORAI 3. |
| Uniprot ID | Q9BRQ5 |
| 基因名全称 | ORAI calcium release-activated calcium modulator 3 |
| 蛋白名全称 | ORAI calcium release-activated calcium modulator 3 |
| 推荐稀释比 | ORAI3 antibody can be used for detection of ORAI3 by Western blot at 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 5μg/mL.Antibody validated:Western Blot in rat samples;Immunohistochemistry in rat samples and Immunofluorescence in human and rat samples.All other applications and species not yet tested. |
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