产品货号：
Z35283
中文名称：
P62/SQSTM1抗体
英文名称：
Anti-P62/SQSTM1 Antibody (Clone#3H11)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-P62/SQSTM1 Antibody (Clone#3H11) |
| 指标别名 | P62;P62/SQSTM1;sequestosome 1;SQSTM1;Ubiquitin binding protein p62 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | SQSTM1 |
| 克隆号 | 3H11 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2a |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human SQSTM1/p62 (69-96aa DEDGDLVAFSSDEELTMAMSYVKDDIFR),identical to the related mouse and rat sequences. |
| 实际分子量 | 62KD |
| 成分 | 200μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | protein G purified. |
| 浓度 | 200μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | SQSTM1(Sequestosome-1),also known as Ubiquitin-Binding Protein P62 or P62,is a protein that in humans is encoded by the SQSTM1 gene.The Src homology type 2(SH2) domain is a highly conserved motif of about 100 amino acids which mediates protein-protein interactions by binding to phosphotyrosine.p56-lck,a T-cell-specific src family tyrosine kinase with an SH2 domain,is involved in T-cell signal transduction.The International Radiation Hybrid Mapping Consortium mapped the p62 gene to chromosome 5q35.Park et al.(1995) found that the p56-lck SH2 domain binds to p62 at the ser59 of p62 only when that serine is phosphorylated.Joung et al.(1996) expressed epitope-tagged p62 in Hela cells and showed that the expressed protein bound to the lck SH2 domain and that this binding was dependent on the N-terminal 50 amino acids of p62 but not on the tyrosine residue in this region. |
| Uniprot ID | Q13501 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P) and ICC. |
| 基因名全称 | sequestosome 1 |
| 蛋白名全称 | Sequestosome-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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