产品货号：
Z35211
中文名称：
MDMX/MDM4抗体
英文名称：
Anti-MDMX/MDM4 Antibody (Clone#OTI4B5)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MDMX/MDM4 Antibody (Clone#OTI4B5) |
| 指标别名 | Double minute 4 protein;HDMX;Mdm2 like p53 binding protein;MDM4;MDMX;MRP1;p53 binding protein Mdm4;Protein Mdm4;Protein Mdmx |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,IF |
| 基因名称 | MDM4 |
| 克隆号 | OTI4B5 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Full length human recombinant protein of human MDM4(NP_002384) produced in HEK293T cell. |
| 实际分子量 | 54.7KD |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus,and shows structural similarity to p53-binding protein MDM2.Both proteins bind the p53 tumor suppressor protein and inhibit its activity,and have been shown to be overexpressed in a variety of human cancers.However,unlike MDM2 which degrades p53,this protein inhibits p53 by binding its transcriptional activation domain.This protein also interacts with MDM2 protein via the RING finger domain,and inhibits the latter's degradation.So this protein can reverse MDM2-targeted degradation of p53,while maintaining suppression of p53 transactivation and apoptotic functions.Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq,Feb 2011] |
| Uniprot ID | O15151 |
| 基因名全称 | Protein Mdm4 |
| 推荐稀释比 | Western blot (WB) 1:200～2000 Immunohistochemistry in paraffin section (IHC) 1:150 Immunofluorescence (IF) 1:100 |
相关搜索：MDMX/MDM4抗体，MDMX抗体，MDM4单抗，Anti-MDMX/MDM4 Antibody (Clone#OTI4B5)