产品货号：
Z35194
中文名称：
MDM2抗体
英文名称：
Anti-MDM2 Antibody (Clone#1806CT309.52.1)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MDM2 Antibody (Clone#1806CT309.52.1) |
| 指标别名 | Double minute 2 protein;hdm2;HDMX;MDM2;Oncoprotein Mdm2;p53 binding protein Mdm2 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | MDM2 |
| 克隆号 | 1806CT309.52.1 |
| 抗体来源 | Mouse |
| 免疫原 | This MDM2 antibody is generated from a mouse immunized with a recombinant protein between 196-435 amino acids from the human MDM2. |
| 计算分子量 | 55kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53,leading to its degradation by the proteasome.Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.Also acts as a ubiquitin ligase E3 toward itself and ARRB1.Permits the nuclear export of p53/TP53.Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation.Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53.Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus.Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. |
| Uniprot ID | Q00987 |
相关搜索：MDM2抗体，MDM2单抗，Anti-MDM2 Antibody (Clone#1806CT309.52.1)