产品货号：
Z35096
中文名称：
MAG抗体
英文名称：
Anti-MAG Antibody (Clone#2G11)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MAG Antibody (Clone#2G11) |
| 指标别名 | GMA;MAG;myelin associated glycoprotein;S MAG;SIGLEC 4A;SIGLEC4A |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF,FCM |
| 基因名称 | MAG |
| 克隆号 | 2G11 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2a |
| 免疫原 | E.coli-derived human MAG recombinant protein (Position:E34-R605). |
| 实际分子量 | 100KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | protein G purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MAG(Myelin-associated glycoprotein),also known as SIGLEC4A,is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor,NgR.It is though to be involved in the process of myelination.MAG is a sialic acid-binding SIGLEC protein and is a functional ligand for the NOGO receptor.The MAG gene is mapped on 19q13.12.Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse,and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth.MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR.MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner.Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG.In cultured human embryonic kidney(HEK) cells expressing the NOGO receptor,p75(NTR) was required for MAG-induced intracellular calcium elevation. |
| Uniprot ID | P20916 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P) and ICC. |
| 基因名全称 | myelin associated glycoprotein |
| 蛋白名全称 | Myelin-associated glycoprotein |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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