产品货号：
Z35083
中文名称：
LEFTY2抗体
英文名称：
Anti-LEFTY2 Antibody (Clone#7C5G1H6H10)
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-LEFTY2 Antibody (Clone#7C5G1H6H10) |
| 指标别名 | EBAF;LEFTA;LEFTY2;LEFTYA;Protein lefty 2;Protein lefty A;TGF beta 4;TGFB4 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | LEFTY2 |
| 克隆号 | 7C5G1H6H10 |
| 抗体来源 | Mouse |
| 免疫原 | A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY. |
| 计算分子量 | 41kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This protein A purified mouse monoclonal antibody reacts with a 30kDa protein corresponding to human LEFTY.No reactivity occurs against 6X HIS tag.Significant sequence homology exists between the human and mouse forms of LEFTY.Cross-reactivity is expected with mouse and rat forms of the protein.Reactivity with other sources has not been determined. |
| 浓度 | 1.0mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | During vertebrate embryogenesis,a left-right axis is established.Secreted growth factors of the TGF-beta family,including gene products derived from nodal,lefty-1 and lefty-2,play crucial roles in establishing left-right asymmetries.TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells.TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors.Complexes formed move into the nucleus,where they act as components of a transcriptional complex.Lefty,a novel member of the TGF-beta superfamily,inhibits TGF-beta signaling.Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor.Lefty also inhibits events downstream from R-Smad phosphorylation.Lefty provides a repressed state of TGF-beta-responsive genes.The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse,and Lefty A and Lefty B in humans.Members of the TGF-beta superfamily require processing for their activation.Cleavage is therefore an essential step for Lefty activation.Lefty is synthesized as a large inactive precursor (42 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28kDa and 34kDa forms).The 28kDa form induces MAPK activity. |
| Uniprot ID | O00292 |
| 基因名全称 | Left-right determination factor 2 |
| 推荐稀释比 | ELISA:1:5,000 WB:1:2,000 |
相关搜索：LEFTY2抗体，LEFTY2单抗，Anti-LEFTY2 Antibody (Clone#7C5G1H6H10)