产品货号：
Z35075
中文名称：
LEF1抗体
英文名称：
Anti-LEF1 Antibody (Clone#1866CT561.78.3)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-LEF1 Antibody (Clone#1866CT561.78.3) |
| 指标别名 | LEF 1;LEF1;TCF1 alpha;TCF1ALPHA |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | LEF1 |
| 克隆号 | 1866CT561.78.3 |
| 抗体来源 | Mouse |
| 免疫原 | This antibody is generated from a mouse immunized with a recombinant protein between 95-283 amino acids from human. |
| 计算分子量 | 44kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Participates in the Wnt signaling pathway.Activates transcription of target genes in the presence of CTNNB1 and EP300.May play a role in hair cell differentiation and follicle morphogenesis.TLE1,TLE2,TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1.Regulates T-cell receptor alpha enhancer function.Binds DNA in a sequence-specific manner.PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity).Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling.Isoform 5 transcriptionally activates the fibronectin promoter,binds to and represses transcription from the E-cadherin promoter in a CTNNB1- independent manner,and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells.Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. |
| Uniprot ID | Q9UJU2 |
相关搜索：LEF1抗体，LEF1单抗，Anti-LEF1 Antibody (Clone#1866CT561.78.3)