产品货号：
Z34955
中文名称：
MEN1抗体
英文名称：
Anti-MEN1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MEN1 Antibody |
| 指标别名 | MEAI;MEN1;Menin;multiple endocrine neoplasia I;SCG2 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF,IP |
| 基因名称 | MEN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Menin Menin,the protein product of the MEN1 gene,is a component of the mixed-lineage leukemia protein (MLL) -containing histone methyltransferase complex that facilitates methylation of histone H3 Lys4 to promote transcriptional activation.Menin functions to suppress proliferation of pancreatic islet cells,at least in part through MLL-mediated activation of the p18INK4c (p18) and p27CIP/KIP (p27) cyclin-dependent kinase inhibitor genes. |
| 实际分子量 | 68KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The MEN1 gene encodes menin,a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling.It is mapped to 11q13.1.MEN1 is considered to act as a tumor suppressor gene.It has been found that that MEN1 inactivation by antisense RNA antagonizes transforming growth factor-beta-mediated cell growth inhibition.Overexpression of MEN1 in an inducible cell culture system downregulated the proximal promoter.In vitro studies have shown that MEN1 is localized to the nucleus,possesses two functional nuclear localization signals,and inhibits transcriptional activation by JunD.What’s more,MEN1 was essential to maintain MLL-associated myeloid transformation. |
| Uniprot ID | O00255 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 |
相关搜索：MEN1抗体，MEN1单抗，Anti-MEN1 Antibody