产品货号：
Z34954
中文名称：
MEKK3/MAP3K3抗体
英文名称：
Anti-MEKK3/MAP3K3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MEKK3/MAP3K3 Antibody |
| 指标别名 | MAP3K3;MAPK/ERK kinase kinase 3;MAPKKK3;MEK kinase 3;MEKK 3;MEKK3 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF |
| 基因名称 | MAP3K3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human MEKK3 |
| 实际分子量 | 71KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MAP3K3(Mitogen-activated protein kinase kinase kinase 3),also known as MAP/ERK KINASE KINASE 3,MEKK3 or MAPKKK3,is an enzyme that in humans is encoded by the MAP3K3 gene.MAP3K3 is contiguously distal to LYK5 on chromosome 17(Puffenberger et al.,2007).By yeast 2-hybrid analysis of a mouse T-cell cDNA library,Uhlik et al.(2003) showed that a C-terminal fragment of mouse Osm(CCM2) interacted with Mekk3,which activates p38 in response to sorbitol-induced hyperosmotic conditions.Mekk3 and Osm colocalized in the cytoplasmic compartment of cotransfected cells,and the Mekk3-Osm complex was recruited to Rac1 and cytoskeletal actin-containing membrane ruffles in response to sorbitol treatment.Protein interaction assays showed that Osm interacted directly with the Mekk3 substrate Mkk3(MAP2K3),with actin,and with both GDP- and GTP-loaded Rac1.Uhlik et al.(2003) concluded that the RAC1-OSM-MEKK3-MKK3 complex is required for regulation of p38 activity in response to osmotic shock. |
| Uniprot ID | Q99759 |
| 基因名全称 | Mitogen-activated protein kinase kinase kinase 3 |
| 推荐稀释比 | Western blot (WB) 1:400～800 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 |
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