产品货号：
Z34515
中文名称：
MKK7/MAP2K7抗体
英文名称：
Anti-MKK7/MAP2K7 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MKK7/MAP2K7 Antibody |
| 指标别名 | JNK activating kinase 2;JNK kinase 2;JNKK 2;Jnkk2;MAP kinase kinase 7;MAP2K7;MAPK/ERK kinase 7;MAPKK 7;MAPKK7;MEK 7;MEK7;MKK7;PRKMK7 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF |
| 基因名称 | MAP2K7 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human MEK7 |
| 实际分子量 | 47KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MAP2K7(Mitogen-activated protein kinase kinase 7),also known as MAP kinase kinase 7,MAPKK7,JNKK2,PRKMK7 or MKK7,is an enzyme that in humans is encoded by the MAP2K7 gene.This protein is a member of the mitogen-activated protein kinase kinase family.The MKK7 protein exists as six different isoforms with three possible N-termini (α,β,and γ isoforms) and two possible C-termini (1 and 2 isoforms).Schramek et al.(2011) showed that the doxorubicin-mediated DNA damage response in human A549 lung carcinoma cells caused rapid phosphorylation and upregulation of p53 (TP53).MKK7 knockdown reduced p53 phosphorylation,delayed p53 upregulation,and interfered with cell cycle arrest at G2/M.MKK7 was activated in primary lung tumors,and tumors with a p53 mutation showed even higher MKK7 phosphorylation.Schramek et al.(2011) concluded that MKK7 exerts its tumor suppressive function through p53. |
| Uniprot ID | O14733 |
| 基因名全称 | Dual specificity mitogen-activated protein kinase kinase 7 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100ICC/IF Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 |
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