产品货号：
Z34375
中文名称：
M-CSFR/CSF1R抗体
英文名称：
Anti-M-CSFR/CSF1R Antibody (Clone#1486CT328.53.37)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-M-CSFR/CSF1R Antibody (Clone#1486CT328.53.37) |
| 指标别名 | C FMS;CD115;CSF 1 R;CSF1R;CSFR;FIM2;FMS;Proto oncogene c Fms |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM,IHC |
| 基因名称 | CSF1R |
| 克隆号 | 1486CT328.53.37 |
| 抗体来源 | Mouse |
| 免疫原 | This CSF1R antibody is generated from a mouse immunized with a recombinant protein. |
| 计算分子量 | 108kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival,proliferation and differentiation of hematopoietic precursor cells,especially mononuclear phagocytes,such as macrophages and monocytes.Promotes the release of proinflammatory chemokines in response to IL34 and CSF1,and thereby plays an important role in innate immunity and in inflammatory processes.Plays an important role in the regulation of osteoclast proliferation and differentiation,the regulation of bone resorption,and is required for normal bone and tooth development.Required for normal male and female fertility,and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy.Promotes reorganization of the actin cytoskeleton,regulates formation of membrane ruffles,cell adhesion and cell migration,and promotes cancer cell invasion.Activates several signaling pathways in response to ligand binding.Phosphorylates PIK3R1,PLCG2,GRB2,SLA2 and CBL.Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate,that then lead to the activation of protein kinase C family members,especially PRKCD.Phosphorylation of PIK3R1,the regulatory subunit of phosphatidylinositol 3-kinase,leads to activation of the AKT1 signaling pathway.Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1,and of the SRC family kinases SRC,FYN and YES1.Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain,or via adapter proteins,such as GRB2.Promotes activation of STAT family members STAT3,STAT5A and/or STAT5B.Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP- 1.Receptor signaling is down-regulated by protein phosphatases,such as INPP5D/SHIP-1,that dephosphorylate the receptor and its downstream effectors,and by rapid internalization of the activated receptor. |
| Uniprot ID | P07333 |
相关搜索：M-CSFR/CSF1R抗体，M-CSFR抗体，CSF1R单抗