产品货号：
Z34193
中文名称：
SYNGAP1抗体
英文名称：
Anti-SYNGAP1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SYNGAP1 Antibody |
| 指标别名 | KIAA1938,MRD5,Neuronal RasGAP,RASA1,RASA5,Synaptic Ras GAP 1,SYNGAP,SYNGAP1 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | SYNGAP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human SynGAP Major constituent of the PSD essential for postsynaptic signaling.Inhibitory regulator of the Ras-cAMP pathway.Member of the NMDAR signaling complex in excitatory synapses,it may play a role in NMDAR-dependent control of AMPAR potentiation,AMPAR membrane trafficking and synaptic plasticity. |
| 实际分子量 | 147KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | SynGAP is a synaptic GTPase-activating protein selectively expressed in the brain and found at higher concentrations specifically at excitatory synapses in the mammalian forebrain.SynGAP has a PH domain,a C2 domain,and a highly conserved RasGAP domain,which negatively regulates both Ras activity and its downstream signaling pathways.SynGAP interacts with the PDZ domains of SAP102,as well as PSD95,a postsynaptic scaffolding protein that couples SynGAP to NMDA receptors (1).SynGAP is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (CaMKII) at Ser765 and Ser1123,among other sites (2,3).Phosphorylation of SynGAP results in stimulation of the GTPase activity of Ras,and PSD95 dependent CaMKII phosphorylation of SynGAP increases after transient brain ischemia (1,4).SynGAP is implicated in NMDAR- and CaMKII-dependent regulation of AMPAR trafficking and plays an important role in synaptic plasticity (3,5).SynGAP is critical during neuronal development as mice lacking SynGAP protein die postnatally.Furthermore,SynGAP mutant mice have reduced long-term potentiation (LTP) and perform poorly in spatial memory tasks (6). |
| Uniprot ID | Q96PV0 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：SYNGAP1抗体，SYNGAP1单抗，Anti-SYNGAP1 Antibody