产品货号：
Z34097
中文名称：
Beta Catenin/CTNNB1抗体(C-term)
英文名称：
Anti-Beta Catenin/CTNNB1 Antibody(C-term)(Clone#691CT11.2.1)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Beta Catenin/CTNNB1 Antibody (C-term) (Clone#691CT11.2.1) |
| 指标别名 | b cat;Beta catenin;beta-Catenin;Catenin beta 1;CTNNB;CTNNB1;PRO2286;β catenin;β-catenin |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IF |
| 基因名称 | CTNNB1 |
| 克隆号 | 691CT11.2.1 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | This CTNNB1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 687-721 amino acids from the C-terminal region of human CTNNB1. |
| 计算分子量 | 85kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Key downstream component of the canonical Wnt signaling pathway.In the absence of Wnt,forms a complex with AXIN1,AXIN2,APC,CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome.In the presence of Wnt ligand,CTNNB1 is not ubiquitinated and accumulates in the nucleus,where it acts as a coactivator for transcription factors of the TCF/LEF family,leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion.Acts as a negative regulator of centrosome cohesion.Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization.Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503,PubMed:18077326,PubMed:18086858,PubMed:18957423,PubMed:21262353,PubMed:22647378,PubMed:22699938,PubMed:22155184).Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). |
| Uniprot ID | P35222 |
相关搜索：Beta Catenin/CTNNB1抗体(C-term)，Beta Catenin抗体，CTNNB1单抗