产品货号：
Z33756
中文名称：
SKP2抗体
英文名称：
Anti-SKP2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SKP2 Antibody |
| 指标别名 | F box protein Skp2;F box/LRR repeat protein 1;FBL1;FBXL1;FLB1;p45skp2;SKP2 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | SKP2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human SKP2 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression,signal transduction and transcription. |
| 实际分子量 | 48KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The F box protein Skp2(S-phase kinase-associated protein 2) is oncogenic,and its frequent amplification and overexpression correlate with the grade of malignancy of certain tumors.Skp2 controls p300-p53 signaling pathways in cancer cells,making it a potential molecular target for cancer therapy.This gene positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators,such as the cell cycle inhibitor p27.This study provides evidence of a role for an F-box protein in oncogenesis and establishes SKP2 as a protooncogene causally involved in the pathogenesis of lymphomas. |
| Uniprot ID | Q13309 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100ICC/IF 1:50～1:200 FC 1:50 |
相关搜索：SKP2抗体，SKP2单抗，Anti-SKP2 Antibody