产品货号：
Z33476
中文名称：
Band 3/AE1/SLC4A1抗体
英文名称：
Anti-Band 3/AE1/SLC4A1 Antibody (Clone#5G2G7)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Band 3/AE1/SLC4A1 Antibody (Clone#5G2G7) |
| 指标别名 | AE 1;AE1;Anion exchange protein 1;Anion exchanger 1;band 3;Band 3 anion transport protein;band 3/AE1;CD233;SLC4A1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,FCM |
| 基因名称 | SLC4A1 |
| 克隆号 | 5G2G7 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | E.coli-derived human Band 3 (Position:E28-N365).Human Band 3 shares 75.7% and 74.5% amino acid (aa) sequence identity with mouse and rat Band 3,respectively. |
| 实际分子量 | 102KD |
| 成分 | Each vial contains 4mg Trehalose,0.9mg NaCl and 0.2mg Na2HPO4. |
| 纯化方式 | protein G/A purified |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Band 3 is also known as SLC4A1.The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane,where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs.The protein comprises two domains that are structurally and functionally distinct.The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin.The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions.The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II.The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger.This protein is predominantly dimeric but forms tetramers in the presence of ankyrin.Many mutations in this gene are known in man,and these mutations can lead to two types of disease:destabilization of red cell membrane leading to hereditary spherocytosis,and defective kidney acid secretion leading to distal renal tubular acidosis.Other mutations that do not give rise to disease result in novel blood group antigens,which form the Diego blood group system. |
| Uniprot ID | P02730 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P) and ICC. |
| 基因名全称 | solute carrier family 4 (anion exchanger),member 1 (Diego blood group) |
| 蛋白名全称 | Band 3 anion transport protein |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Flow Cytometry (FCM) 1～3μg/1×106 cells Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
相关搜索：Band 3/AE1/SLC4A1抗体，Band 3抗体，AE1抗体，SLC4A1单抗，Anti-Band 3/AE1/SLC4A1 Antibody (Clone#5G2G7)