产品货号：
Z33236
中文名称：
Annexin A1/ANXA1抗体
英文名称：
Anti-Annexin A1/ANXA1 Antibody (Clone#6B7F8)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Annexin A1/ANXA1 Antibody (Clone#6B7F8) |
| 指标别名 | Annexin 1;annexin A1;Annexin I;ANX1;ANXA1;Calpactin 2;Calpactin II;Chromobindin 9;Lipocortin I;LPC1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,FCM |
| 基因名称 | ANXA1 |
| 克隆号 | 6B7F8 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | E.coli-derived human Annexin A1 recombinant protein (Position:A2-N346).Human Annexin A1 shares 88% and 89% amino acid (aa) sequence identity with mouse and rat Annexin A1,respectively. |
| 实际分子量 | 35～39KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ANXA1,also known as lipocortin I or Annexin A1,is a protein that in humans is encoded by the ANXA1 gene.It is mapped to 9q21.13.ANXA1 belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane.ANXA1 protein has an apparent relative molecular mass of 40kDa,with phospholipase A2 inhibitory activity.Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway.This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge.These findings identified ANXA1 peptides as novel,endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects. |
| Uniprot ID | P04083 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P). |
| 基因名全称 | annexin A1 |
| 蛋白名全称 | Annexin A1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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