产品货号：
Z33131
中文名称：
Alpha A Crystallin/CRYAA抗体
英文名称：
Anti-Alpha A Crystallin/CRYAA Antibody (Clone#OTI3B12)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Alpha A Crystallin/CRYAA Antibody (Clone#OTI3B12) |
| 指标别名 | CRYAA;Acry 1;CRYA 1;CRYA1;CRYAA;Crystallin alpha 1;Crystallin alpha A;HSPB 4 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF |
| 基因名称 | CRYAA |
| 克隆号 | OTI3B12 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | Full length human recombinant protein of human CRYAA(NP_000385) produced in HEK293T cell. |
| 实际分子量 | 19.7KD |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | Crystallins are separated into two classes:taxon-specific,or enzyme,and ubiquitous.The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens.Since lens central fiber cells lose their nuclei during development,these crystallins are made and then retained throughout life,making them extremely stable proteins.Mammalian lens crystallins are divided into alpha,beta,and gamma families;beta and gamma crystallins are also considered as a superfamily.Alpha and beta families are further divided into acidic and basic groups.Seven protein regions exist in crystallins:four homologous motifs,a connecting peptide,and N- and C-terminal extensions.Alpha crystallins are composed of two gene products:alpha-A and alpha-B,for acidic and basic,respectively.Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family.They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone;instead they hold them in large soluble aggregates.Post-translational modifications decrease the ability to chaperone.These heterogeneous aggregates consist of 30-40 subunits;the alpha-A and alpha-B subunits have a 3:1 ratio,respectively.Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture.Alpha-A and alpha-B gene products are differentially expressed;alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs.Defects in this gene cause autosomal dominant congenital cataract (ADCC).[provided by RefSeq] |
| Uniprot ID | P02489 |
| 基因名全称 | crystallin alpha A |
| 蛋白名全称 | Alpha-crystallin A chain |
| 推荐稀释比 | Western blot (WB) 1:2000 Immunohistochemistry in paraffin section (IHC) 1:150 Immunofluorescence (IF) 1:100 |
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