产品货号：
Z33102
中文名称：
Alpha E-Catenin/CTNNA1抗体
英文名称：
Anti-Alpha E-Catenin/CTNNA1 Antibody (Clone#10I2)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Alpha E-Catenin/CTNNA1 Antibody (Clone#10I2) |
| 指标别名 | alpha catenin;Alpha E catenin;Alpha E-Catenin;Cadherin associated protein;CAP102;Catenin alpha 1;CTNNA1;α-catenin;α-E-catenin;αE-catenin |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,FCM |
| 基因名称 | CTNNA1 |
| 克隆号 | 10I2 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | E.coli-derived human CTNNA1 recombinant protein (Position:D143-D292).Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1. |
| 实际分子量 | 100KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | protein G purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CTNNA1,also known as Catenin alpha-1 or Catenin (cadherin-associated protein),alpha 1,is a protein that in humans is encoded by the CTNNA1 gene.It is mapped to 5q31.2.When surface epithelium CTNNA1 was ablated,hair follicle development was blocked and epidermal morphogenesis was dramatically affected,with defects in adherens junction formation,intercellular adhesion,and epithelial polarity.In vitro,CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly.These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein,desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses.It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1. |
| Uniprot ID | P35221 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P) and ICC. |
| 基因名全称 | catenin (cadherin-associated protein),alpha 1,102kDa |
| 蛋白名全称 | Catenin alpha-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry(Paraffin-embedded Section) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
相关搜索：Alpha E-Catenin/CTNNA1抗体，Alpha E-Catenin抗体，CTNNA1单抗，Anti-Alpha E-Catenin/CTNNA1 Antibody (Clone#10I2)