产品货号：
Z33033
中文名称：
AKT1抗体
英文名称：
Anti-AKT1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AKT1 Antibody |
| 指标别名 | AKT;AKT1;PKB;PKB ALPHA;PRKBA;Protein kinase B;Proto oncogene c Akt;RAC;RAC ALPHA;RAC PK alpha |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,IP |
| 基因名称 | AKT1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human AKT1 Akt,also referred to as PKB or Rac,plays a critical role in controlling survival and apoptosis.This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase.Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473. |
| 实际分子量 | 56～60KD |
| 成分 | Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene.The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts.AKT1 and the related AKT2 are activated by platelet-derived growth factor.The activation is rapid and specific,and it is abrogated by mutations in the pleckstrin homology domain of AKT1.It was shown that the activation occurs through phosphatidylinositol 3-kinase.In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival.Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1,which then phosphorylates and inactivates components of the apoptotic machinery.Mutations in this gene have been associated with the Proteus syndrome.Multiple alternatively spliced transcript variants have been found for this gene. |
| Uniprot ID | P31749 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 |
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