产品货号：
Z32655
中文名称：
AEG-1/MTDH抗体
英文名称：
Anti-AEG-1/MTDH Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AEG-1/MTDH Antibody |
| 指标别名 | 3D3;3D3/LYRIC;AEG 1;AEG1;LYRIC;LYRIC/3D3;metadherin;Metastasis adhesion protein;MTDH;Protein LYRIC |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | MTDH |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human LYRIC Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically.Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor.Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. |
| 实际分子量 | 70～80KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MTDH (Metadherin),also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene.AEG-1 is involved in HIF-1alpha mediated angiogenesis.AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very important role in RISC and miRNA functions.AEG-1 induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis.Late SV40 factor (LSF/TFCP2) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).AEG-1 acts as an oncogene in melanoma,malignant glioma,breast cancer and hepatocellular carcinoma.It is highly expressed in these cancers and helps in progression and development of these cancers.It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells. |
| Uniprot ID | Q86UE4 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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