产品货号：
Z32400
中文名称：
CRKL抗体
英文名称：
Anti-CRKL Antibody (Clone#23C70)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CRKL Antibody (Clone#23C70) |
| 指标别名 | CRK like proto-oncogene;adaptor protein;CRKL |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF |
| 基因名称 | CRKL |
| 克隆号 | 23C70 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human CRKL |
| 实际分子量 | 39KD |
| 成分 | Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol,0.5mg/mL BSA. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CRKL(v-crk sarcoma virus CT10 oncogene homolog(avian)-like) also called ONCOGENE°CRKL,encodes a 303-amino acid polypeptide with a predicted molecular mass of 36kD.While°CRKL is not the human homolog of CRK,it is similar to protein-tyrosine kinases with SH2 and SH3(src homology) domains.By fluorescence in situ hybridization,the°CRKL gene is localized to chromosome 22q11,centromeric of the chronic myelogenous leukemia breakpoint region.Senechal et al.(1996) showed that°CRKL becomes phosphorylated when overexpressed,activates Ras-dependent and JNK pathways,and transforms fibroblasts.The authors also found°CRKL to be a substrate for the BCR-ABL tyrosine kinase,leading them to conclude thatCRKL is a tyrosine kinase and an oncogene.Crkl was required for normal cellular responses to Fgf8,including survival and migration,Erk activation,and target gene expression. |
| Uniprot ID | P46109 |
| 基因名全称 | v-crk sarcoma virus CT10 oncogene homolog(avian)-like |
| 蛋白名全称 | Crk-like protein |
| 推荐稀释比 | Western blot (WB) 1:500～1000 IHC 1:50～1:200 ICC/IF 1:50～1:200 |
相关搜索：CRKL抗体，CRKL单抗，Anti-CRKL Antibody (Clone#23C70)