产品货号：
Z32399
中文名称：
CRKL抗体
英文名称：
Anti-CRKL Antibody (Clone#5E12)
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CRKL Antibody (Clone#5E12) |
| 指标别名 | CRK like proto-oncogene;adaptor protein;CRKL |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM,ELISA |
| 基因名称 | CRKL |
| 克隆号 | 5E12 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG |
| 免疫原 | Purified recombinant fragment of human Crk-L expressed in E.Coli. |
| 计算分子量 | 34KD |
| 成分 | Ascitic fluid containing 0.03% sodium azide. |
| 纯化方式 | Affinity purification |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | CRKL(v-crk sarcoma virus CT10 oncogene homolog(avian)-like) also called ONCOGENE°CRKL,encodes a 303-amino acid polypeptide with a predicted molecular mass of 36kD.While°CRKL is not the human homolog of CRK,it is similar to protein-tyrosine kinases with SH2 and SH3(src homology) domains.By fluorescence in situ hybridization,the°CRKL gene is localized to chromosome 22q11,centromeric of the chronic myelogenous leukemia breakpoint region.Senechal et al.(1996) showed that°CRKL becomes phosphorylated when overexpressed,activates Ras-dependent and JNK pathways,and transforms fibroblasts.The authors also found°CRKL to be a substrate for the BCR-ABL tyrosine kinase,leading them to conclude thatCRKL is a tyrosine kinase and an oncogene.Crkl was required for normal cellular responses to Fgf8,including survival and migration,Erk activation,and target gene expression. |
| Uniprot ID | P46109 |
| 基因名全称 | Crk-like protein |
| 蛋白名全称 | Crk-like protein |
| 推荐稀释比 | WB 1:500～1:2000 FC 1:200～1:400 ELISA 1:10000 |
相关搜索：CRKL抗体，CRKL单抗，Anti-CRKL Antibody (Clone#5E12)