产品货号:
Z32235
中文名称:
CD10/MME抗体
英文名称:
Anti-CD10/MME Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-CD10/MME Antibody |
指标别名 | Atriopeptidase;CALLA;CD10;Enkephalinase;EPN;membrane metallo endopeptidase;MME;MME;CD10;NEP;Neprilysin;Neutral endopeptidase;Neutral endopeptidase 24.11 |
克隆性 | Monoclonal |
检验物种 | human,rat |
应用范围 | WB |
基因名称 | MME |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | A synthesized peptide derived from human CD10 CD10 is a transmembrane type II molecule and functions as a metallo-peptidase requiring zinc.Specifically,CD10 cleaves 1-3 amino-terminal amino acids from peptides with a preference for neutral amino acids (valine,iso-leucine,phenylalanine,leucine or alanine).Involved in the degradation of atrial natriuretic factor (ANF). |
实际分子量 | 100KD |
成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
纯化方式 | Affinity-chromatography |
浓度 | 500μg/mL |
产品形态 | 溶液 |
保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
背景资料 | CD10,also known as membrane metallo-endopeptidase,neutral endopeptidase(NEP),Neprilysin,or common acute lymphoblastic leukemia antigen(CALLA),is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides,most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease.This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization.By cDNA transfection analysis,CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase.CD10 has also been called atriopeptidase.Atriopeptidase specifically degrades atrial natriuretic factor.A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion.These effects include diuresis,natriuresis,vasodilatation,and suppression of the renin-angiotensin-aldosterone system. |
Uniprot ID | P08473 |
推荐稀释比 | Western blot (WB) 1:500~2000 |
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