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产品目录

Caspase 3/CASP3 (p17)抗体图片
产品货号:
Z32186
中文名称:
Caspase 3/CASP3 (p17)抗体
英文名称:
Anti-Caspase 3/CASP3 (p17) Antibody (Clone#8B6)
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-Caspase 3/CASP3 (p17) Antibody (Clone#8B6)
指标别名Apopain;CASP 3;CASP3;Caspase 3;Caspase 3/p17;Caspase3;CPP 32;CPP32;CPP32B;Cysteine protease CPP32;Protein Yama;SCA 1;SREBP cleavage activity 1
克隆性Monoclonal
检验物种human
应用范围WB,IHC,FCM
基因名称CASP3
克隆号8B6
抗体来源Mouse
抗体类型IgG1
免疫原E.coli-derived human Caspase-3 recombinant protein (Position:T67-D175).Human Caspase-3 shares 86% and 90% amino acid (aa) sequence identity with mouse and rat Caspase-3,respectively.
实际分子量35KD
成分500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式protein G purified.
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料Caspase 3 is a caspase protein which interacts with Survivin,XIAP,CFLAR,Caspase 8,HCLS1,Deleted in Colorectal Cancer,TRAF3 and GroEL.This gene which is located on 4q35 encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits,large and small,that dimerize to form the active enzyme.It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein,which is associated with neuronal death in Alzheimer's disease.And the caspase-3 activation in heart failure sequentially cleaves SRF and generates a truncated SRF that appears to function as a dominant-negative transcription factor.Additionally,the caspase-3 influence on bone mineral density should be considered in any in vivo application of caspase-3 inhibitors to the treatment of human disease.In erythroid precursors undergoing terminal differentiation,Hsp70 prevents active CASP3 from cleaving GATA1 and inducing apoptosis.
Uniprot IDP42574
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P) and ICC.
推荐稀释比
Western blot(WB) 1:500~2000
Immunohistochemistry in paraffin section (IHC) 1:50~400
Flow cytometry (FCM) 1~3μg/1×106 cells
(Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user.

相关搜索:Caspase 3/CASP3 (p17)抗体Caspase 3抗体CASP3 (p17)单抗Anti-Caspase 3/CASP3 (p17) Antibody (Clone#8B6)
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