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产品目录

Caspase 3/CASP3(active+pro)抗体图片
产品货号:
Z32176
中文名称:
Caspase 3/CASP3(active+pro)抗体
英文名称:
Anti-Caspase 3/CASP3(active+pro) Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-Caspase 3/CASP3(active+pro) Antibody
指标别名Apopain;CASP 3;CASP3;Caspase 3;Caspase 3/p17;Caspase3;CPP 32;CPP32;CPP32B;Cysteine protease CPP32;Protein Yama;SCA 1;SREBP cleavage activity 1
克隆性Monoclonal
检验物种human
应用范围WB,IHC,IP
基因名称CASP3
抗体来源Rabbit
抗体类型IgG
免疫原A synthesized peptide derived from human active + pro Caspase 3
实际分子量35KD
成分500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol.
纯化方式Affinity-chromatography
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料Caspase 3 is a caspase protein which interacts with Survivin,XIAP,CFLAR,Caspase 8,HCLS1,Deleted in Colorectal Cancer,TRAF3 and GroEL.This gene which is located on 4q35 encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits,large and small,that dimerize to form the active enzyme.It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein,which is associated with neuronal death in Alzheimer's disease.And the caspase-3 activation in heart failure sequentially cleaves SRF and generates a truncated SRF that appears to function as a dominant-negative transcription factor.Additionally,the caspase-3 influence on bone mineral density should be considered in any in vivo application of caspase-3 inhibitors to the treatment of human disease.In erythroid precursors undergoing terminal differentiation,Hsp70 prevents active CASP3 from cleaving GATA1 and inducing apoptosis.
Uniprot IDP42574
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。
基因名全称Caspase-3
推荐稀释比
Western blot (WB) 1:500~2000
Immunohistochemistry in paraffin section (IHC) 1:20~100
Immunocoprecipitation 1:20

相关搜索:Caspase 3/CASP3(active+pro)抗体Caspase 3抗体CASP3(active+pro)单抗Anti-Caspase 3/CASP3(active+pro) Antibody
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