产品货号：
Z31752
中文名称：
DLAT抗体
英文名称：
Anti-DLAT Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-DLAT Antibody |
| 指标别名 | DLAT;DLTA;PBC;PDC E2;PDCE2 |
| 克隆性 | Monoclonal |
| 检验物种 | human,rabbit |
| 应用范围 | WB |
| 基因名称 | DLAT |
| 抗体来源 | Mouse |
| 免疫原 | Purified recombinant human PDC-E2 protein fragments expressed in E.coli. |
| 计算分子量 | 69KD |
| 成分 | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH7.4,150mM NaCl) with 0.2% sodium azide,50% glycerol. |
| 纯化方式 | Protein A purified |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | Dihydrolipoyl transacetylase (or dihydrolipoamide acetyltransferase) is an enzyme component of the multienzyme pyruvate dehydrogenase complex.This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC).PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A.The protein product of this gene,dihydrolipoamide acetyltransferase,accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A.Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies.These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC).In PBC,activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed.PBC enventually leads to cirrhosis and liver failure.Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood. |
| Uniprot ID | P10515 |
| 基因名全称 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex,mitochondrial |
| 推荐稀释比 | WB,1:1000～1:2000 |
相关搜索：DLAT抗体，DLAT单抗，Anti-DLAT Antibody