加入收藏
百奥莱博公司客服电话百奥莱博QQ百奥莱博QQ百奥莱博QQ
百奥莱博公司微信服务号

产品目录

CD45/PTPRC抗体图片
产品货号:
Z31413
中文名称:
CD45/PTPRC抗体
英文名称:
Anti-CD45/PTPRC Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-CD45/PTPRC Antibody
指标别名B220;CD45;CD45R;GP180;L CA;LCA;Leukocyte common antigen;LY5;PTPRC;RPTPC;T200
克隆性Monoclonal
检验物种human
应用范围WB,IHC
基因名称PTPRC
抗体来源Rabbit
抗体类型IgG
免疫原A synthesized peptide derived from human CD45
实际分子量180~250KD
成分500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol.
纯化方式Affinity-chromatography
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料CD45(Cluster of Differentiation 45),also known as PTPRC,LCA or CD45R,is an enzyme that,in humans,is encoded by the PTPRC gene.CD45 is a member of the protein tyrosine phosphatase (PTP) family.CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase.The cytogenetic location of CD45 is 1q31.3-q32.1.This gene is especially a prototype for transmembrane protein-tyrosine phosphatase (PTP).Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins.In vitro,CD45 directly dephosphorylates and binds to JAKs.Functionally,CD45 negatively regulates interleukin-3-mediated cellular proliferation,erythropoietin-dependent hematopoiesis,and antiviral responses in vitro and in vivo.CD45 has been best studied in T cells,where it determines T cell receptor signaling thresholds.CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton.Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.
Uniprot IDP08575
基因名全称Receptor-type tyrosine-protein phosphatase C
推荐稀释比
Western blot (WB) 1:500~2000
Immunohistochemistry in paraffin section (IHC) 1:20~100

相关搜索:CD45/PTPRC抗体CD45抗体PTPRC单抗Anti-CD45/PTPRC Antibody
首页 |  关于我们 |  联系我们 |  在线咨询 |  网站地图
北京百奥莱博科技有限公司 京ICP备14007103号-3