产品货号：
Z31375
中文名称：
CTCF抗体
英文名称：
Anti-CTCF Antibody (Clone#1723CT382.14.9)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CTCF Antibody (Clone#1723CT382.14.9) |
| 指标别名 | 11 zinc finger protein;CCCTC binding factor;CTCF;CTCFL paralog;Transcriptional repressor CTCF |
| 克隆性 | Monoclonal |
| 检验物种 | human,rat |
| 应用范围 | WB |
| 基因名称 | CTCF |
| 克隆号 | 1723CT382.14.9 |
| 抗体来源 | Mouse |
| 免疫原 | This CTCF antibody is generated from a mouse immunized with a recombinant protein between 445-727 amino acids from human CTCF. |
| 计算分子量 | 83kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Chromatin binding factor that binds to DNA sequence specific sites.Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers.Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene.Also binds to the PLK and PIM1 promoters.Acts as a transcriptional activator of APP.Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression.Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription.Seems to act as tumor suppressor.Plays a critical role in the epigenetic regulation.Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus.On the maternal allele,binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2.Plays a critical role in gene silencing over considerable distances in the genome.Preferentially interacts with unmethylated DNA,preventing spreading of CpG methylation and maintaining methylation-free zones.Inversely,binding to target sites is prevented by CpG methylation.Plays a important role in chromatin remodeling.Can dimerize when it is bound to different DNA sequences,mediating long-range chromatin looping.Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory.Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus,without affecting transcription.When bound to chromatin,it provides an anchor point for nucleosomes positioning.Seems to be essential for homologous X-chromosome pairing.May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation.May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation.Involved in sister chromatid cohesion.Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites.Regulates asynchronous replication of IGF2/H19. |
| Uniprot ID | P49711 |
相关搜索：CTCF抗体，CTCF单抗，Anti-CTCF Antibody (Clone#1723CT382.14.9)