产品货号：
Z31354
中文名称：
CUL3抗体
英文名称：
Anti-CUL3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CUL3 Antibody |
| 指标别名 | CUL 3;CUL3;cullin 3;KIAA0617 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | CUL3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Cullin 3 Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. |
| 实际分子量 | 89KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Cullin-3(Cul 3),is a protein that in humans is encoded by the CUL3 gene.Kipreos et al.(1996) identified a conserved gene family,designated cullins,with at least 5 members in nematodes,6 in humans,and 3 in S.cerevisiae.Human CUL3 is an ortholog of nematode cul3.Hartz(2012) mapped the CUL3 gene to chromosome 2q36.2 based on an alignment of the CUL3 sequence with the genomic sequence(GRCh37).Sumara et al.(2007) found that KLHL9,KLHL13,and CUL3 interacted directly in a 370-kD protein complex in HeLa cell lysates.Rondou et al.(2008) showed that interaction between KLHL12 and the CUL3 ubiquitin ligase complex directed ubiquitination of dopamine receptor D4(DRD4).KLHL12 interacted directly with CUL3 and with the polymorphic intracellular loop-3 of D4.By immunoprecipitation analysis of HeLa cells and HCT116 human colon carcinoma cells expressing epitope-tagged proteins,Kigoshi et al.(2011) showed that KLHL7 interacted with CUL3 and ROC1(RBX1). |
| Uniprot ID | Q13618 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：CUL3抗体，CUL3单抗，Anti-CUL3 Antibody