产品货号：
Z31173
中文名称：
DTL抗体
英文名称：
Anti-DTL Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-DTL Antibody |
| 指标别名 | CDT2;CDW1;DCAF2;Denticleless protein homolog;DTL;L2DTL;RAMP |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | DTL |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human CDT2 Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control,DNA damage response and translesion DNA synthesis.The DCX (DTL) complex,also named CRL4 (CDT2) complex,mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21 (CIP1). |
| 实际分子量 | 91KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CDT2,also named as L2DTL or RAMP,is one of the substrate receptors of the Cullin Ring Ubiquitin Ligase 4 that targets for ubiquitin mediated degradation a number of substrates,such as CDT1,p21 and CHK1,involved in the regulation of cell cycle and survival.CDT2 overexpression was reported in breast (PMID:18542055),gastric (PMID:19672268) and ovarian carcinomas (PMID:23995842) and rhabdomyosarcomas (PMID:19235922) and associated with the aggressiveness of hepatocellular carcinomas (PMID:17106265). |
| Uniprot ID | Q9NZJ0 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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