产品货号：
Z31114
中文名称：
Emerin/EMD抗体
英文名称：
Anti-Emerin/EMD Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Emerin/EMD Antibody |
| 指标别名 | EDMD;EMD;Emerin;LEMD5;STA |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF |
| 基因名称 | EMD |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Emerin Emerin may regulate gene expression through binding to other transcriptional regulators.Emerin binds to Beta -catenin and inhibits its nuclear accumulation.Recent studies demonstrate that Emerin is required for HIV-1 infectivity. |
| 实际分子量 | 34KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Emerin is a serine-rich nuclear membrane protein that in humans is encoded by the EMD gene.And this gene is mapped to Xq28.Emerin is a member of the nuclear lamina-associated protein family.It mediates membrane anchorage to the cytoskeleton.Emery–Dreifuss muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the EMD (also known clinically as STA) gene.Emerin appears to be involved in mechanotransduction,as emerin-deficient mouse fibroblasts failed to transduce normal mechanosensitive gene expression responses to strain stimuli.In cardiac muscle,emerin is also found complexed to beta-catenin at adherens junctions of intercalated discs,and cardiomyocytes from hearts lacking emerin showed beta-catenin redistribution as well as perturbed intercalated disc architecture and myocyte shape.This interaction appears to be regulated by glycogen synthase kinase 3 beta. |
| Uniprot ID | P50402 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 |
相关搜索：Emerin/EMD抗体，Emerin抗体，EMD单抗，Anti-Emerin/EMD Antibody