产品货号：
Z30179
中文名称：
ZP2抗体
英文名称：
Anti-ZP2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ZP2 Antibody |
| 指标别名 | zona pellucida glycoprotein 2;OOMD6;ZPA;Zp-2;ZP2 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,IHC-F |
| 基因名称 | ZP2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human ZP2 (511-544aa ENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDD),different from the related mouse sequence by six amino acids,and from the related rat sequence by four amino acids. |
| 实际分子量 | 82KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Zona pellucida sperm-binding protein 2 is a protein that in humans is encoded by the ZP2 gene.The sperm-binding domain on the ZP2 protein is necessary in both humans and mice for oocyte-sperm recognition and penetration of the zona pellucida.It is also responsible for the primary block to polyspermy in mammals.The oocyte has cortical granules peripherally located under the cortex that contain a proteolytic protein called ovastacin.After the sperm binds to ZP2,the cortical granules are exocytosed releasing ovastacin into the perivitelline space.Ovastacin cleaves ZP2 at the N terminus,preventing more sperm from binding and penetrating the oocyte,thus hardening the zona pellucida.Ovastacin is only found in oocytes,and is part of the astacin family of metalloendoproteases.Female mice engineered without ovastacin showed that ZP2 was not cleaved after fertilization. |
| Uniprot ID | Q05996 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | zona pellucida glycoprotein 2 (sperm receptor) |
| 蛋白名全称 | Zona pellucida sperm-binding protein 2 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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