产品货号：
Z30141
中文名称：
ZBTB7A抗体
英文名称：
Anti-ZBTB7A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ZBTB7A Antibody |
| 指标别名 | zinc finger and BTB domain containing 7A;FBI-1;FBI1;LRF;TIP21;ZBTB7;ZNF857A;pokemon;ZBTB7A |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | ZBTB7A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human ZBTB7A (125-163aa DLLDRQILAADAGADAGQLDLVDQIDQRNLLRAKEYLEF),different from the related mouse sequence by eleven amino acids,and from the related rat sequence by ten amino acids. |
| 实际分子量 | 72KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.ZBTB7A has a critical oncosuppressive role in the prostate.Prostate-specific inactivation of ZBTB7A leads to a marked acceleration of PTEN loss-driven prostate tumorigenesis through bypass of PTEN loss-induced cellular senescence.It has been showed that ZBTB7A physically interacts with SOX9 and functionally antagonizes its transcriptional activity on key target genes such as MIA,which is involved in tumor cell invasion,and H19,a long noncoding RNA precursor for an RB-targeting microRNA.Inactivation of ZBTB7A in vivo leads to RB downregulation,bypass of PTEN loss-induced cellular senescence,and invasive prostate cancer.Notably,it has been also found that ZBTB7A is genetically lost,as well as downregulated at both the mRNA and protein levels,in a subset of human advanced prostate cancers.Therefore,ZBTB7A is identified as a context-dependent cancer gene that can act as an oncogene in some contexts but that also has oncosuppressive-like activity in PTEN-null tumors. |
| Uniprot ID | O95365 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | zinc finger and BTB domain containing 7A |
| 蛋白名全称 | Zinc finger and BTB domain-containing protein 7A |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow Cytometry(FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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