产品货号：
Z30074
中文名称：
CUL2抗体
英文名称：
Anti-CUL2 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CUL2 Antibody |
| 指标别名 | CUL 2;CUL2;cullin 2 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | IHC,IP,WB |
| 基因名称 | CUL2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-Cul2 was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-Terminus region near amino acids 720-745 of Human Cul2 coupled to KLH. |
| 成分 | 0.01% (w/v) Sodium Azide |
| 纯化方式 | Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.This product reacts with human Cullin 2.Cross-reactivity with Cul2 from other sources has not been determined. |
| 浓度 | 85mg/mL by Refractometry |
| 产品形态 | 溶液 |
| 保存条件 | Store Cul2 antibody at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Anti-Cul2 antibody can be used in western blotting,ELISA and IP.Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination,as well as binding to various specificity factors to recruit substrates.Cullin 2 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex,which mediates the ubiquitination of proteins involved in cell cycle progression,signal transduction and transcription.In the SCF complex,cul2 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits.Cul2 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.Cul2 is part of the SCF complex consisting of CUL1,RBX1,SKP1 and SKP2,where it interacts directly with SKP1,SKP2 and RBX1.Cul2 also interacts with RNF7 and is part of a complex with TIP120A/CAND1 and RBX1.The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. |
| Uniprot ID | Q13617 |
| 推荐稀释比 | ELISA:1:2,000 - 1:10,000 IHC:User Optimized IP:1:500 WB:1:500 - 1:1,000 |
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