产品货号：
Z29763
中文名称：
XBP1S-specific抗体
英文名称：
Anti-XBP1S-specific antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-XBP1S-specific antibody |
| 指标别名 | TREB5;X box binding protein 1;XBP 1;XBP1;XBP1s;XBP-1S;XBP1U;XBP2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | XBP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human XBP1S-specific recombinant protein (Position:A165-I374). |
| 实际分子量 | 29KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | XBP1,also known as X-box binding protein 1,is a protein which in humans is encoded by the XBP1 gene.It encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box.This gene product is a bZIP protein,which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter.It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER),the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1).The resulting loss of 26nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S),which is the functionally active transcription factor.The isoform encoded by the unspliced mRNA,XBP1(U),is constitutively expressed,and thought to function as a negative feedback regulator of XBP1(S),which shuts off transcription of target genes during the recovery phase of ER stress.A pseudogene of XBP1 has been identified and localized to chromosome 5. |
| Uniprot ID | P17861 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | X-box binding protein 1 |
| 蛋白名全称 | X-box-binding protein 1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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