产品货号：
Z29562
中文名称：
VISA/MAVS抗体
英文名称：
Anti-VISA/MAVS Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-VISA/MAVS Antibody |
| 指标别名 | CARDIF;IPS 1;IPS1;KIAA1271;MAVS;MAVS;VISA;VISA |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | MAVS |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | VISA antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human VISA.The immunogen is located within the first 50 amino acids of VISA. |
| 计算分子量 | 57kDa |
| 成分 | VISA Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | VISA Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Two distinct signaling pathways activate the host innate immunity against viral infection.One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response.VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I,leading to its activation and that of NF-百B.VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF,TRAF2 and TRAF6.VISA also interacts with the IKK汐，IKK汕and IKK汍kinases through its C-terminal region.Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system.At least three isoforms of VISA are known to exist. |
| Uniprot ID | Q7Z434 |
| 基因名全称 | Mitochondrial antiviral signaling protein |
| 蛋白名全称 | Mitochondrial antiviral signaling protein |
| 推荐稀释比 | VISA antibody can be used for detection of VISA by Western blot at 0.5 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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