产品货号：
Z29506
中文名称：
UAP56/DDX39B抗体
英文名称：
Anti-UAP56/DDX39B Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-UAP56/DDX39B Antibody (C-term) |
| 指标别名 | ATP dependent RNA helicase p47;BAT1;D6S81E;DDX39;DDX39B;DEAD box protein UAP56;HLA B associated transcript 1;Spliceosome RNA helicase BAT1;UAP56 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM,IHC |
| 基因名称 | DDX39B |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This BAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from the C-terminal region of human BAT1. |
| 计算分子量 | 49kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Component of the THO subcomplex of the TREX complex.The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA.It is recruited to spliced mRNAs by a transcription-independent mechanism.Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export.The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1.UAP56 functions as a bridge between THOC4 and the THO complex.The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint.It has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity.Even with the stimulation of RNA,the ATPase activity is weak.It can only hydrolyze ATP but not other NTPs.The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA.However,ssRNA stimulates the ATPase activity much more strongly than dsRNA.It can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro.The ATPase and helicase activities are not influenced by U2AF2 and THOC4. |
| Uniprot ID | Q13838 |
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