产品货号：
Z29380
中文名称：
UHRF1抗体
英文名称：
Anti-UHRF1 Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-UHRF1 Antibody (C-term) |
| 指标别名 | hNP95;HuNp95;ICBP90;Nuclear protein 95;RING finger protein 106;RNF106;Transcription factor ICBP90;UHRF1 |
| 克隆性 | Polyclonal |
| 检验物种 | mouse |
| 应用范围 | WB |
| 基因名称 | Uhrf1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This Mouse Uhrf1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 596-628 amino acids from the C-terminal region of Mouse Uhrf1. |
| 计算分子量 | 88kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification.Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication.In addition to its role in maintenance of DNA methylation,also plays a key role in chromatin modification:through its tudor-like regions and PHD- type zinc fingers,specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0),respectively,and recruits chromatin proteins.Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication.Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications.Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML.It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo.May be involved in DNA repair. |
| Uniprot ID | Q8VDF2 |
相关搜索：UHRF1抗体，UHRF1(C-term)多抗，Anti-UHRF1 Antibody (C-term)