产品货号：
Z29321
中文名称：
VDR抗体
英文名称：
Anti-VDR Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-VDR Antibody |
| 指标别名 | VDR;NR1I1;Vitamin D3 receptor;VDR;1;25-dihydroxyvitamin D3 receptor;Nuclear receptor subfamily 1 group I member 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | VDR |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human VDR (377-402aa HLLYAKMIQKLADLRSLNEEHSKQYR),different from the related mouse and rat sequences by one amino acid. |
| 实际分子量 | 48KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | VDR (Vitamin D Receptor),also known as Vitamin D Hormone Receptor,is a member of the nuclear receptor family of transcription factors.Labuda et al.(1991) assigned the VDR gene to 12q12-q14 by in situ hybridization.Using mutation analysis,Jurutka et al.(2000) characterized arg18/arg22,VDR residues immediately N-terminal of the first DNA-binding zinc finger,as vital for contact with the general transcription factor IIB (TFIIB).A natural polymorphic variant of VDR,termed F/M4 (missing a FokI restriction site),which lacks only the first 3 amino acids (including glu2),interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length (f/M1) receptor.Shah et al.(2006) stated that the signaling and oncogenic activity of beta-catenin (CTNNB1) can be repressed by activation of VDR.Conversely,high levels of beta-catenin can potentiate the transcriptional activity of 1,25- dihydroxyvitamin D3. |
| Uniprot ID | P11473 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
| 蛋白名全称 | Vitamin D3 receptor |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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