产品货号：
Z29300
中文名称：
VCAN抗体
英文名称：
Anti-VCAN Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-VCAN Antibody |
| 指标别名 | versican;CSPG2;ERVR;GHAP;PG-M;WGN;WGN1;VCAN |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | VCAN |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Versican (65-92aa KWSKIEVDKNGKDLKETTVLVAQNGNIK),different from the related mouse and rat sequences by two amino acids. |
| 实际分子量 | 373KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Versican (VCAN),also known as CSPG2,is a large extracellular matrix proteoglycan that is present in a variety of human tissues.Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000kDa.The Versican gene is mapped on 5q14.2-q14.3.The human versican gene contains 15 exons spanning more than 90kb.The distribution of versican by using affinity-purified polyclonal antibodies that recognize the core protein of the prominent versican splice variants V0 and V1.Versican staining was noted in the central and peripheral nervous system,in the basal layer of the epidermis,and on the luminal surface of some glandular epithelia.Biochemical purification of LLC-conditioned medium led to identification of the extracellular matrix proteoglycan versican,which is upregulated in many human tumors including lung cancer,as a macrophage activator that acts through TLR2 and its coreceptors TLR6 and CD14.By activating TLR2:TLR6 complexes and inducing TNF-alpha secretion by myeloid cells,versican strongly enhances LLC metastatic growth. |
| Uniprot ID | P13611 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | versican |
| 蛋白名全称 | Versican core protein |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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