产品货号：
Z29299
中文名称：
VCAM1抗体
英文名称：
Anti-VCAM1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-VCAM1 Antibody |
| 指标别名 | CD106;INCAM 100;V CAM 1;VCAM 1;VCAM1 |
| 克隆性 | Polyclonal |
| 检验物种 | mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | VCAM1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of mouse VCAM1(653-671aa YTIRQAQLQDAGIYECESK),different from the related human sequence by three amino acids,and from the related rat sequence by two amino acids. |
| 实际分子量 | 85～110KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CD106(cluster of differentiation 106) also known as vascular cell adhesion molecule 1(VCAM-1),is a protein that in humans is encoded by the VCAM1 gene.In inflammatory conditions and in cardiac allografts undergoing rejection,VCAM1 is upregulated in endothelium of postcapillary venules.Arterial expression of VCAM1 is also found in experimental models of atherosclerosis in the rabbit.Cybulsky et al.(1991) mapped the VCAM1 gene to chromosome 1 by Southern analysis of somatic cell hybrids.Kumar et al.(1994) mapped the murine Vcam1 gene to chromosome 3 near Amy1.VCAM-1 functions as a cell adhesion molecule.The VCAM-1 protein mediates the adhesion of lymphocytes,monocytes,eosinophils,andbasophils to vascularendothelium.It also functions in leukocyte-endothelial cell signal transduction,and it may play a role in the development ofatherosclerosis and rheumatoid arthritis.CAM741 works similar to cotransin in that it represses the biosynthesis of VCAM1 cells by blocking the process of cotranslational translocation,which is dependent on the signal peptide ofVCAM1.Among the lung metastasis signature genes identified,several,includingVCAM1,were functionally validated. |
| Uniprot ID | P29533 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | vascular cell adhesion molecule 1 |
| 蛋白名全称 | Vascular cell adhesion protein 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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