产品货号：
Z29208
中文名称：
TTBK1抗体
英文名称：
Anti-TTBK1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TTBK1 Antibody |
| 指标别名 | BDTK,BDTK,KIAA1855,Tau-tubulin kinase 1,Brain-derived tau kinase |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | TTBK1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | TTBK1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TTBK1.The immunogen is located within amino acids 1190 - 1240 of TTBK1. |
| 计算分子量 | 143kDa |
| 成分 | TTBK1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | TTBK1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein.It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner.TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients,and mice expressing human TTBK1 protein showed significant age-dependent memory impairment.These mice displayed increased levels of the CDK5 activators p25 and p35,and reduced levels of the NMDA receptor types 2B and 2D,suggesting that TTBK1 may play a role in memory dysfunction in AD patients. |
| Uniprot ID | Q5TCY1 |
| 基因名全称 | Tau tubulin kinase 1 |
| 蛋白名全称 | Tau tubulin kinase 1 |
| 推荐稀释比 | TTBK1 antibody can be used for detection of TTBK1 by Western blot at 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in mouse samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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