产品货号：
Z29127
中文名称：
TORC1/CRTC1抗体
英文名称：
Anti-TORC1/CRTC1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TORC1/CRTC1 Antibody |
| 指标别名 | CRTC1;KIAA0616;MECT1;TORC 1;TORC1;TORC1/CRTC1;Transducer of CREB protein 1;WAMTP1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,FCM,ELISA |
| 基因名称 | CRTC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human TORC1/CRTC1 recombinant protein (Position:E30-E568). |
| 实际分子量 | 78KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CRTC1 (CREB-Regulated Transcription Coactivator 1),also known as MECT1,TORC1 or KIAA0616,is a protein that in humans is encoded by the CRTC1 gene.By sequence analysis,Tonon et al.(2003) mapped the CRTC1 gene to chromosome 19p13.Kovacs et al.(2007) found that Torc1 was expressed in adult mouse brain and cultured neurons,and that it translocated to the nucleus upon concomitant activation of calcium and cAMP signaling pathways.Mair et al.(2011) demonstrated that CRTC1 is a direct AMPK target,and interacts with the CREB homolog-1 (CRH1) transcription factor in vivo.The prolongevity effects of activating AMPK or deactivating calcineurin decrease CRTC1 and CRH1 activity and induce transcriptional responses similar to those of CRH1-null worms. |
| Uniprot ID | Q6UUV9 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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