产品货号：
Z28903
中文名称：
Ubiquilin 1/UBQLN1抗体
英文名称：
Anti-Ubiquilin 1/UBQLN1 Antibody (Center)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Ubiquilin 1/UBQLN1 Antibody (Center) |
| 指标别名 | DA41,DSK2,hPLIC 1,PLIC 1,PLIC1,ubiquilin 1,UBQLN1,XDRP1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | IF,WB,IHC |
| 基因名称 | UBQLN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This Ubiquilin1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-326 amino acids from the Central region of human Ubiquilin1. |
| 计算分子量 | 63kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Ubiquilin 1 (UBQLN1),also known as DA41,was isolated from an adult rat lung cDNA library,and encodes a cellular protein that associates with DAN.1 DAN expression is reduced in rat fibroblast 3Y1 cells transformed with mouse sarcoma virus and in rodent fibroblasts transformed with a variety of oncogenes.The DAN-DA41 interaction is mediated through the N-terminal domain and a cysteine-knot region of DAN.Human DA41 encodes a 589-amino acid protein with 86% amino acid sequence identity with rat protein.2 DA41 expression is regulated in a cell cycle-dependent manner.PLIC1 and PLIC2 (UBQLN2) are homologs of the mouse Plics (proteins linking integrin-associated protein (IAP) and cytoskeleton) and the yeast Dsk2 protein.PLIC1,also called UBQLN1,shares 72% amino acid identity with PLIC2,3 Two motifs are conserved in the mammalian PLICs and yeast Dsk2,an N-terminal ubiquitin-like (UBL) domain and a C-terminal ubiquitin-associated (UBA) domain.Unlike ubiquitin,the UBL domain of the PLICs does not have a diglycine motif in its C terminus.The UBA domain is present in multiple enzyme classes of the ubiquitination machinery.Human PLICs associate with both proteasomes and ubiquitin ligases in large complexes.Overexpression of PLICs impairs the in vivo degradation of 2 unrelated ubiquitin-dependent proteasome substrates,p53 and I-kappa-B-alpha (NFKBIA),but not a ubiquitin-independent substrate.PLICs may link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.The DA41 gene maps to chromosome 9q21.2-q21.3,a position overlapping a candidate tumor suppressor locus for bladder cancer.2 |
| Uniprot ID | Q9UMX0 |
相关搜索：Ubiquilin 1/UBQLN1抗体，Ubiquilin 1抗体，UBQLN1(Center)多抗，Anti-Ubiquilin 1/UBQLN1 Antibody (Center)