产品货号：
Z28817
中文名称：
TRIF/TICAM1抗体
英文名称：
Anti-TRIF/TICAM1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TRIF/TICAM1 Antibody |
| 指标别名 | PRVTIRB;TICAM 1;TICAM1;TRIF;TRIF/TICAM1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,IHC-F |
| 基因名称 | TICAM1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human TRIF(692-712aa NNHMWNQRGSQAPEDKTQEAE). |
| 实际分子量 | 110KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | TICAM(TIR DOMAIN-CONTAINING ADAPTOR MOLECULE 1),also known as TICAM1 or TRIF,is an adapter in responding to activation of toll-like receptors(TLRs).It mediates the rather delayed cascade of two TLR-associated signaling cascades,where the other one is dependent upon a MyD88 adapter.By genomic sequence analysis,Oshiumi et al.(2003) mapped the TICAM1 gene to chromosome 19p13.3.By coimmunoprecipitation analysis,Oshiumi et al.(2003) showed that TICAM1 interacts specifically with TLR3,but not with other TLRs.Functional analysis showed that the association of TLR3 and TICAM1 mediates dsRNA activation of IFNB,through either NFKB,AP1,or IRF3.TICAM1 activation of NFKB was found to occur predominantly through IRAK1 rather than IRAK2.Small interfering(si)RNA blockage of TICAM1,just upstream of the TIR domain,reduced IFNB production in response to dsRNA. |
| Uniprot ID | Q8IUC6 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | toll-like receptor adaptor molecule 1 |
| 蛋白名全称 | TIR domain-containing adapter molecule 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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