产品货号：
Z28742
中文名称：
TREX1抗体
英文名称：
Anti-TREX1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TREX1 Antibody |
| 指标别名 | 3 5 exonuclease TREX1;AGS1;AGS5;CRV;DNase III;DRN3;HERNS;TREX1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | TREX1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | TREX1 antibody was raised against a 15 amino acid synthetic peptide near the center of human TREX1.The immunogen is located within amino acids 220 - 270 of TREX1. |
| 计算分子量 | 33kDa |
| 成分 | TREX1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | TREX1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Trex1 is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage.It is ubiquitously expressed,binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR),a checkpoint kinase,to sites of DNA damage and replication stress.Trex1 is required for ATR expression.This gene uses two different open reading frames.The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint.The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III.Mutations in this gene result in Aicardi-Goutieres syndrome,chilblain lupus,and Cree encephalitis. |
| Uniprot ID | Q9NSU2 |
| 基因名全称 | Three prime repair exonuclease 1 |
| 蛋白名全称 | Three prime repair exonuclease 1 |
| 推荐稀释比 | TREX1 antibody can be used for detection of TREX1 by Western blot at 0.5 and 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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